RecruitingNot Applicable

PostoperAtive Neurocognitive Dysfunction After Major AbdomiNal Surgery (PANDAMAN)

China500 participantsStarted 2023-12-11

Plain-language summary

Predisposing and precipitating factors for perioperative delirium for the elderly remain elusive. This research will be conducted to determine risk factors of postoperative delirium.

Who can participate

Age range65 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. 65 to 90 years old to receive elective major abdominal surgery (expected operation time over 2 hours); ,
✓. American society of Aneshesiologists（ASA）physical status I-III;

Exclusion criteria

✕. Mini-Mental State Examination (MMES) score \< 15;
✕. Renal failure (requiring dialysis) or liver failure (Child-Pugh score \> 5);
✕. Severe impairment due to structural or hypoxic brain injury, more than 2 days in ICU one month before surgery;
✕. Underwent major heart, lung or abdominal surgery within 1 year;
✕. Positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or symptomatic (e.g. fever, cough, loss of taste/smell);
✕. The cognitive assessment cannot be completed because the subject is blind, deaf, or unable to communicate in the local language;
✕. Long-term follow-up unavailable (homelessness, active psychosis or substance abuse).

What they're measuring

Incidence of delirium during first 7 days after surgery

Timeframe: Consecutive 7 days after the surgery or hospital discharge, whichever comes first.

Trial details

NCT IDNCT06182215

SponsorSixth Affiliated Hospital, Sun Yat-sen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

Contact for this trial

Xiangcai Ruan, MD, PhD

+86-13760710099 ruanxc@mail.sysu.edu.cn

View on ClinicalTrials.gov More Elective Major Abdominal Surgery trials