The purpose of this study is to measure the safety, tolerability PK and PD of inhaled AGMB-477 compared with placebo in healthy participants and participants with IPF. This is an integrated phase 1, single center, 3-part, double-blind, randomized, placebo-controlled SAD (Part A) and MAD (Part B) study in healthy participants and multiple dose study in IPF participants (Part C). Safety, tolerability PK and PD will be assessed following single ascending, multiple ascending and multiple dosing of AGMB-447 administered via nebulizer in Part A, B and C, respectively.
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of participants with adverse events
Timeframe: From Screening Through Study Completion, up to 8 Weeks
Number of participants with abnormal clinical laboratory values
Timeframe: From Screening Through Study Completion, up to 8 Weeks
Number of participants with abnormal ECG parameters
Timeframe: From Screening Through Study Completion, up to 8 Weeks
Number of participants with abnormal vital signs
Timeframe: From Screening Through Study Completion, up to 8 Weeks
Number of participants with abnormal physical exams
Timeframe: From Screening Through Study Completion, up to 8 Weeks
Number of participants with abnormal spirometry parameters
Timeframe: From Screening Through Study Completion, up to 8 Weeks