Pre-hospital ECMO or Conventional Resuscitation for Refractory Cardiac Arrest (NCT06177730) | Clinical Trial Compass
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Pre-hospital ECMO or Conventional Resuscitation for Refractory Cardiac Arrest
10 participantsStarted 2024-03
Plain-language summary
This pilot study aims to determine feasibility of randomising patients to receive pre-hospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) compared to conventional cardiac arrest care for refractory out of hospital cardiac arrest (OHCA).
The success of this study will be measured by the number of patients recruited into the study successfully treated with the treatment they were randomised to receive in the pre-Hospital setting.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients 18-70 years old
* Witnessed cardiac arrest
* Bystander CPR
* Refractory cardiac arrest (\>20 mins, but \<45 mins)
* Initial cardiac rhythm VF, VT or PEA
* Within hours of PACER service operation (e.g. mon-fri 0800-1700)
* Within 25 mins of rapid response ambulance (code 1 lights and sirens)
Exclusion Criteria:
* Initial cardiac rhythm asystole
* ROSC with sustained recovery
* Technically not possible to perform percutaneous cannulation
* Evidence of/suspectedSignificant end stage disease:
* Severe disability impairing activities of daily living
* End-stage organ - cardiac, liver, lung, renal
* Other life-limiting diseases e.g malignancy, terminal illness
* Advance health care directive (not for resuscitation)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of patients in each group that are successfully initiated on ECMO.
Timeframe: 6 months
Trial details
NCT IDNCT06177730
SponsorAustralian and New Zealand Intensive Care Research Centre