Active — Not RecruitingNot Applicable

Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study

South Africa2,500 participantsStarted 2023-07-17

Plain-language summary

The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.

Who can participate

Age range16 Years – 30 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 16 years - 30 years old, * Self-report living without HIV or unknown status. * Persons who have been sexually active within the last 3 months * Interested in the use of PrEP for HIV prevention. * Able and willing to provide informed consent for study procedures. * Access to a cellphone for study related communication * Reside in the study community for the duration of follow-up. Exclusion Criteria: * HIV infection based on negative HIV rapid tests * Clinically ineligible for PrEP * The participant doesn't reside in the study community for the duration of follow-up

What they're measuring

The primary outcome is uptake of Pre-exposure prophylaxis of HIV (PrEP) .

Timeframe: 36 Months

Trial details

NCT IDNCT06176859

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05

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