Parasite Clearance and Protection From Infection (PCPI) in Cameroon (NCT06173206) | Clinical Trial Compass
CompletedPhase 3
Parasite Clearance and Protection From Infection (PCPI) in Cameroon
Cameroon902 participantsStarted 2024-06-10
Plain-language summary
The Cameroon PCPI study will measure the effect of the parasite genotypes associated with SP resistance on parasite clearance and protection from infection when exposed to SP. The total number of participants is expected to be 900 healthy between 3 to 5 years old who have no symptoms of malaria infection of which 450 children will be assigned to the SP group, 250 to the SPAQ group, and 200 to the AS group. The results of this study will allow to measure the effect of the parasite genotypes associated with SP resistance on parasite clearance and protection from infection when exposed to SP.
Who can participate
Age range
3 Years – 5 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Be 3-5 years old
* Exhibit no symptoms of malaria
* Have parents/guardians willing to have their child participate in all follow-up visits and seek care from study staff
* Reside in the study catchment area
Exclusion Criteria:
* Have evidence of acute illness as determined by clinical examination
* Exhibit symptoms of malaria (axillary fever ≥ 37.5 °C and / or history of fever in past 48 hours)
* Have known allergy to study medications
* Have received antimalarial treatment or azithromycin within 28 days prior to screening
* Be concomitantly receiving co-trimoxazole (trimethoprim-sulfamethoxazole)
* Be categorised as severely malnourished according to WHO child growth standards
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Parasite clearance
Timeframe: 28 days (total follow up 63 days post SP dose)
2
Protection from infection
Timeframe: 28 days (total follow up 63 days post SP dose)
Trial details
NCT IDNCT06173206
SponsorLondon School of Hygiene and Tropical Medicine