CompletedNot Applicable

The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.

Italy31 participantsStarted 2022-10-01

Plain-language summary

The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Who can participate

Age range18 Years – 32 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18 to 32 years who required both M3M extractions were recruited * Good health status * Indication to surgical extraction of both M3M * Complete root formation * Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification Exclusion Criteria: * Person under the age of 18 or over 32 * Allergy or contraindications to administration of corticosteroids * Acute infection in any of the teeth to be extracted * Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease * Pregnancy or breastfeeding * History of treatment with antiresorptive drugs * Chronic kidney disease

What they're measuring

Facial swelling qualitative analysis

Timeframe: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery

Facial swelling quantitative analysis - volumetric differences

Timeframe: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery

Facial swelling quantitative analysis - linear differences

Timeframe: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery

Trial details

NCT IDNCT06165692

SponsorAmerigo Giudice

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-01

View on ClinicalTrials.gov More Facial Swelling trials