CompletedNot Applicable

Carbetocin in the Prevention of Primary Postpartum Haemorrhage

Egypt244 participantsStarted 2023-01-01

Plain-language summary

Postpartum haemorrhage (PPH) ranks as the first cause of maternal mortality in developing countries and it is the cause of 25% of maternal deaths worldwide. Carbetocin is a long-acting synthetic octapeptide analogue of oxytocin with agonist properties. Like oxytocin, carbetocin binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions and increased uterine tone.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 20-40years. * Body mass index (BMI): Obese ≥30 kg/m2 and non-obese women \<30 kg/m2 calculated using maternal height and weight measured to the nearest centimeter and kilogram, respectively, at time of admission to labor word. * Gestational age: Gestational age ≥37 weeks (gestational age will be recorded according to the last menstrual period and confirmed by ultrasound). In case of discrepancy, a 1st trimesteric ultrasound will be taken as the actual gestational age. * Singleton pregnancy. Exclusion Criteria: Patients who have any factors that might increase the risk of postpartum haemorrhage will be excluded as anemic patients (Hb\<10.5g%), antepartum haemorrhage ( placenta previa, placental abruption ), uterine myomata, multiple gestation, polyhydramnios. * Patients with pre-existing bleeding or thromboembolic disorder. * Patients with chronic medical diseases (cardiac, hepatic, renal)

What they're measuring

Post postpartum bleeding

Timeframe: first 6 hours after the Cesarean Section

Trial details

NCT IDNCT06159959

SponsorMinistry of Health and Population, Egypt

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-10-01