CompletedNot Applicable

Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants

Italy67 participantsStarted 2020-01-01

Plain-language summary

Proning manoeuvre as an early treatment for acute severe hypoxic respiratory failure has been implemented recently during the COVID-19 pandemic. This method was proposed more than fifty years ago to improve gas exchange : Proning Severe ARDS (PROSEVA) trial, however, was the milestone which demonstrated mortality benefit in patients with severe ARDS. Nevertheless, few analysis were performed on the effects of the prone position after lung transplantion (LT). The aim of the study is therefore to relate LT primary graft dysfunction (PGD) pathophysiology, which occurs in postoperative setting, to prone-positioning effects on ventilation-perfusion matching, improved lung compliance and clinical outcomes of impairedorgan patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 y.o. * First bilateral lung transplant * PGD grade 2 or 3 within 24 hours from ICU admission Admission to ICU for post-operative monitoring after LTx * Written informed consent obtained Exclusion Criteria: * Age \< 18 years old * PGD\<2 * Single transplant * Re-transplant * IMV, venous-venous (V-V) or venous-arterial (V-A) extracorporeal membrane oxygenation (ECMO) before surgery * Contraindications to prone positioning * Refusal of consent

What they're measuring

28-day ventilator free days

Timeframe: From ICU admission up to 28 post-operative days (POD)

Trial details

NCT IDNCT06159933

SponsorUniversity of Padova

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-04-30

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