Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive. The mouth has a protective shield called salivary pellicle that helps, and there are some special bacteria called Nitrate-reducing bacteria (NRB) that can be good for the mouth and heart. Eating some fruits and vegetables or drinking beetroot can make these bacteria thrive, which might help the heart and blood pressure. This study wants to see how drinking beetroot juice affects these good bacteria in your mouth for people with healthy teeth and those with erosion. This study aims to find out if drinking beetroot juice can change the saliva and bacteria in the mouth for the better, in people with both healthy teeth and those with dental erosion. The proposed study is part of a PhD educational project and will be a double blind, randomised design, crossover trial for the effect of nitrate supplement on healthy control and people with dental erosion (PwDE). This study aims to explore the effect of nitrate supplement on oral microbiome in WMS and SP and its impact on blood pressure and arterial stiffness in healthy controls and PwDE.
Age range
18 Years – 75 Years
Sex
ALL
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Identification of salivary proteins via SDS-PAGE Electrophoresis:
Timeframe: December 2024
Identification of salivary proteins via Proteomics analysis:
Timeframe: Baseline (day -7), post each intervention (i.e. Beetroot juice and placebo) on day 1
Microbiome diversity using DNA extraction and 16s ribosomal RNA analysis
Timeframe: Baseline (day -7), post each intervention (i.e. Beetroot juice and placebo) on day 1