TMS for Inhibition Enhancement in Schizophrenia (NCT06155682) | Clinical Trial Compass
RecruitingNot Applicable
TMS for Inhibition Enhancement in Schizophrenia
United States34 participantsStarted 2026-02-02
Plain-language summary
This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decrease in the short-interval intracortical inhibition (SICI) score from pre-to-post-treatment. We will also collect preliminary data on the effect of rTMS on the resting functional connectivity of the motor cortex and other brain regions and the relationship of change in SICI to change in cognitive performance
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion criteria
✓. Age 18-45 years
✓. Male or Female
✓. Able to participate in the informed consent process and provide voluntary informed consent.
✓. A Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) diagnosis of schizophrenia documented by the Structured Clinical Interview for DSM-5 (SCID-5)
Exclusion criteria
✕. A history of a DSM-5 substance misuse disorder (other than caffeine or tobacco or mild marijuana misuse) within the past six months; or a positive baseline urine drug screen.
✕. A history of a current neurological disorder (including, but not limited to Parkinson's Disease, epilepsy, or Multiple Sclerosis)
✕. History of head trauma resulting in unconsciousness
✕. Contraindications for TMS, including any history of seizure other than febrile seizure, presence of ferromagnetic metal in cranium, presence of cochlear implant, presence of deep brain stimulation (DBS) electrodes based on medical history
What they're measuring
1
The change in the short interval intracortical inhibition (SICI) score