Identification of Factors Predictive of the Efficacy of Endoscopic Endoscopic Sleeve Gastroplasty

Inclusion Criteria: * Patient of legal age (Age ≥ 18 years) * Patient capable of understanding the study and signing a consent. * BMI between 30 and 35 kg/m² with the presence of at least one one obesity-related complication (diabetes, dyslipidemia, sleep apnea syndrome, non-alcoholic steatohepatitis, joint pain joint pain). * Patients with a BMI greater than 35 kg/m² who have been bariatric surgery has been refused. * Patient who has failed to lose weight and improve with conventional techniques. * Patient affiliated to a social security scheme Exclusion Criteria: * Patient having taken antibiotics 3 months prior to inclusion. * Patient under legal protection. * Patient at risk of gastric cancer requiring regular endoscopic surveillance: extensive intestinal atrophy and/or metaplasia on biopsy. * Patient with a history of gastrointestinal inflammatory disease of gastric localization, hepatic or renal insufficiency, portal hypertension. * Patient with evidence of peptic ulcer disease and/or progressive peptic ulcer disease. * Patient with pathology affecting general health health and/or life expectancy. * Patient with a history of bariatric surgery. * Patient on AME