RecruitingPhase 3

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

United States120 participantsStarted 2024-04-01

Plain-language summary

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * B/S1 hypertension * SBP 100-139 average based on 3 office measurements. * Age 18 or Older * Previous COA Repair Exclusion Criteria: * Currently on beta blocker (BB) therapy * Pregnancy/lactating * eGFR\<30 * Hyperkalemia (serum potassium \>5.5mmol/L) * Severe Aortic or Mitral valve stenosis or regurgitation * Epicardial CAD diagnosis * Received antihypertensive medications within the past year

What they're measuring

Change in Left Ventricular (LV) Fibrosis

Timeframe: Baseline; Week 52

Trial details

NCT IDNCT06150560

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06-01

Contact for this trial

ACHD Research Program

(507) 293-2565 RSTACHDRESPRG@mayo.edu

View on ClinicalTrials.gov More Coarctation of Aorta trials