Liver and Spleen Stiffness Measured by TE and 2D-SWE for Diagnosis of CSPH in Patients With cACLD

Inclusion Criteria: * Age≥18 years old; * Chronic liver disease (alcoholic liver disease, chronic hepatitis B, chronic hepatitis C or non-alcoholic fatty liver disease); * Liver stiffness ≥10kPa measured by transient elastography (TE); * No previous decompensation-related manifestations (such as ascites, gastrointestinal varicose bleeding, hepatic encephalopathy, etc.); * Informed consent has been signed. Exclusion Criteria: * There are contraindications of hepatic venous pressure gradient (HVPG) measurement (such as severe abnormal coagulation function; * Non-cirrhosis portal hypertension; * Hepatocellular carcinoma or other advanced malignant tumor; * Acute liver disease or ALT≥5×ULN; * A history of splenectomy or splenic embolism; * Acute or chronic thrombosis of the portal vein; * Pregnancy or HIV infection; * A history of using non-selective beta blockers (NSBB) or diuretic in the last 3 months; * Persistent substance abuse other than alcohol; * A history of transjugular intrahepatic portosystemic shunts (TIPs), endoscopic variceal ligation(EVL) , hardener or tissue gel therapy; * There are conditions that seriously affect TE and 2D-SWE measurements (such as the intercostal space is too narrow, BMI≥30, etc.); * Subjects considered unsuitable for including in this study but not included by the above exclusion criteria.