Liver and Spleen Stiffness Measured by 2D-SWE for Diagnosis of Liver Fibrosis in Patients With cACLD

Inclusion Criteria: * Age≥18 years old; * Chronic liver disease (alcoholic liver disease, chronic hepatitis B, chronic hepatitis C or non-alcoholic fatty liver disease); * No previous decompensation-related manifestations (such as ascites, gastrointestinal varicose bleeding, hepatic encephalopathy, etc.); * Informed consent has been signed. Exclusion Criteria: * Hepatocellular carcinoma or other advanced malignant tumor; * Acute liver disease or ALT≥5×ULN; * Persistent substance abuse other than alcohol; * Pregnancy or HIV infection; * There are contraindications of percutaneous liver biopsy (such as serious abnormality of coagulation function, etc.); * There are conditions that seriously affect TE and 2D-SWE measurements (such as the intercostal space is too narrow, BMI≥30, etc.); * Subjects considered unsuitable for including in this study but not included by the above exclusion criteria.