RecruitingNot Applicable

Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

United Kingdom230 participantsStarted 2024-02-08

Plain-language summary

There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Aged 18 years or above * Patient: known or suspected airway disease * Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.) Exclusion Criteria: * Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus. * Surgery within the preceding 6 weeks * Participants who are pregnant * History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection * Alcohol or recreational drug abuse * Diagnosis of immunodeficiency requiring treatment * Unable to provide written informed consent * Unable to read or write English * Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This study is collecting blood samples to look at immune system patterns in people with COPD, asthma, or airway disease — what exactly would they be looking for in my blood, and what would that mean for my care?
2Since this trial is labeled 'Phase NA,' it seems to be an observational or sample-collection study rather than a treatment trial — does that mean there's no experimental treatment involved, and what would actually be asked of me as a participant?
3Would taking part in this study give me or my doctors any useful information about my specific condition, or is the data primarily being used for research purposes that might benefit future patients rather than me directly?
4Given that I'm already managing my airway disease, could participating in this study conflict with or delay any standard treatments my care team has planned for me?
5Are there any risks associated with the blood draws or other procedures in this study that I should weigh before deciding whether to discuss enrollment with you?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Blood samples for presence of airway disease immune endotypes

Timeframe: 6 years

Trial details

NCT IDNCT06144476

SponsorGuy's and St Thomas' NHS Foundation Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-31

Contact for this trial

Gillian Radcliffe, MRes

02071888070 gillian.radcliffe@gstt.nhs.uk

View on ClinicalTrials.gov More COPD trials