Stopped: PI transferring work elsewhere
Rates of heavy drinking and Alcohol Use Disorder (AUD) are increasing in women, but research on alcohol-related harms in women - including alcohol's impact on sleep - has been minimal. Numerous studies in men show that alcohol impairs sleep, and preliminary evidence suggests that women may be even more sensitive to alcohol-disrupted sleep due to their sex hormones, which fluctuate across both their menstrual cycles and their reproductive lifespans. This study will investigate the influence of sex, menstrual cycle phase, and sex hormones on alcohol-disrupted sleep in adults ages 21-45. Healthy women and men will complete two sets of placebo-controlled lab sessions, during the mid-follicular and late luteal phases of female participants' menstrual cycles. During these sessions, participants will receive a dose of alcohol or a placebo (saline) and they will then be monitored (with polysomnography) while they sleep. At-home sleep and alcohol use will also be measured through actigraphy, daily sleep and wake diaries, and alcohol wrist sensors. Investigators hypothesize that women will show greater disruption of sleep following alcohol use or administration than men, and that alcohol-disrupted sleep will be more pronounced in the late luteal phase compared to the mid-follicular phase. Investigators also expect that estradiol will be negatively associated with alcohol-disrupted sleep, whereas progesterone will be positively associated with alcohol-disrupted sleep.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Slow Wave Sleep Minutes
Timeframe: Night 1 (alcohol administration, late luteal phase; 8 hours)
Slow Wave Sleep Minutes
Timeframe: Night 2 (placebo, late luteal phase; 8 hours)
Slow Wave Sleep Minutes
Timeframe: Night 3 (alcohol administration, mid-follicular phase; 8 hours)
Slow Wave Sleep Minutes
Timeframe: Night 4 (placebo, mid-follicular phase; 8 hours)
Rapid Eye Movement Sleep Minutes
Timeframe: Night 1 (alcohol administration, late luteal phase; 8 hours)
Rapid Eye Movement Sleep Minutes
Timeframe: Night 2 (placebo, late luteal phase; 8 hours)
Rapid Eye Movement Sleep Minutes
Timeframe: Night 3 (alcohol administration, mid-follicular phase; 8 hours)
Rapid Eye Movement Sleep Minutes
Timeframe: Night 4 (placebo, mid-follicular phase; 8 hours)
Wake After Sleep Onset
Timeframe: Night 1 (alcohol administration, late luteal phase; 8 hours)
Wake After Sleep Onset
Timeframe: Night 2 (placebo, late luteal phase; 8 hours)
Wake After Sleep Onset
Timeframe: Night 3 (alcohol administration, mid-follicular phase; 8 hours)
Wake After Sleep Onset
Timeframe: Night 4 (placebo, mid-follicular phase; 8 hours)
Sleep Efficiency
Timeframe: Night 1 (alcohol administration, late luteal phase; 8 hours)
Sleep Efficiency
Timeframe: Night 2 (placebo, late luteal phase; 8 hours)
Sleep Efficiency
Timeframe: Night 3 (alcohol administration, mid-follicular phase; 8 hours)
Sleep Efficiency
Timeframe: Night 4 (placebo, mid-follicular phase; 8 hours)