Intermittent Theta Burst Stimulation of the Precuneus (NCT06142422) | Clinical Trial Compass
WithdrawnNot Applicable
Intermittent Theta Burst Stimulation of the Precuneus
Stopped: The sponsor decided to terminate the study early on April 21, 2026. No patients were enrolled in this study.
0Started 2026-01
Plain-language summary
The purpose of the study is to compare the effectiveness of stimulation of the left precuneus by intermittent Theta Burst Stimulation to placebo stimulation on the severity of schizophrenia symptoms.
Who can participate
Age range18 Years – 40 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Right-handed patient aged 18 to 40 years inclusive;
* Patient presenting schizophrenia as defined in the Diagnostic and Statistical Manual-5;
* Patient under antipsychotic treatment in accordance with the recommendations of the High Authority of Health, at a stable dosage and without modification of psychotherapeutic treatment for at least 4 weeks;
* Patient on mono or dual antipsychotic therapy.
* Patient presenting residual symptoms, i.e. absence of remission defined by the criteria of the "Remission criteria of the Schizophrenia Working Group Consensus";
* Patient having been exposed to at least one type of trauma in childhood and having a score higher than the threshold values of the childhood trauma questionnaire: emotional neglect, physical abuse, emotional abuse, physical neglect, sexual abuse;
* Patient having signed an informed consent form to participate in the study.
Exclusion Criteria:
* Patient with a contraindication to magnetic resonance imaging or intermittent Theta Burst Stimulation (presence of a metallic body, pacemaker, implantable defibrillator or other implantable metallic device, epilepsy, stroke or recent head trauma);
* Patient who is not French-speaking or cannot read and write;
* Patient under guardianship;
* Patient in forced care (psychiatric care upon decision of the State representative and psychiatric care at the request of a third party);
* Pregnant woman or likely to be pregnant (of childbearing age) without effective…
What they're measuring
1
average of the Scale for assessment of negative symptoms/scale for assessment of positive symptoms scale scores