Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)

Inclusion Criteria: * Age ≥18 years old, age ≤80 years old * Patients with atrial fibrillation detected by routine surface 12-lead electrocardiography or Holter * Transesophageal echocardiography confirmed the presence of cardiac thrombus, and the patient had not received any anticoagulant therapy Exclusion Criteria: * Echocardiography confirmed valvular heart disease * Contraindications to anticoagulants * Patients with the previous history of hemorrhagic stroke * Low platelet count or functional platelet defects * Congenital or acquired coagulation or bleeding disorders * Abnormal liver function (liver enzymes \>2 times the upper limit) * Renal failure (endogenous creatinine clearance \<30ml/min) * Surgery was planned within the intended study time or had been operated within 30 days before the study * Other comorbidities that can cause bleeding, such as tumors * Patients with autoimmune diseases or immunodeficiency, or patients who are currently using immunosuppressants and immunomodulators * Patients are currently participating in other clinical studies