Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrilla… (NCT06141538) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)
China500 participantsStarted 2024-12-31
Plain-language summary
This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus. Additionally, the study aims to analyze factors that influence the responsiveness and occurrence of adverse events related to anticoagulant therapy.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years old, age ≤80 years old
* Patients with atrial fibrillation detected by routine surface 12-lead electrocardiography or Holter
* Transesophageal echocardiography confirmed the presence of cardiac thrombus, and the patient had not received any anticoagulant therapy
Exclusion Criteria:
* Echocardiography confirmed valvular heart disease
* Contraindications to anticoagulants
* Patients with the previous history of hemorrhagic stroke
* Low platelet count or functional platelet defects
* Congenital or acquired coagulation or bleeding disorders
* Abnormal liver function (liver enzymes \>2 times the upper limit)
* Renal failure (endogenous creatinine clearance \<30ml/min)
* Surgery was planned within the intended study time or had been operated within 30 days before the study
* Other comorbidities that can cause bleeding, such as tumors
* Patients with autoimmune diseases or immunodeficiency, or patients who are currently using immunosuppressants and immunomodulators
* Patients are currently participating in other clinical studies
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Success rate of thrombolysis
Timeframe: 1，2，3 months after enrollment.
2
Change of incidence of MACCE
Timeframe: 1，2，3 months after enrollment.
Trial details
NCT IDNCT06141538
SponsorFirst Affiliated Hospital Xi'an Jiaotong University