Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery

Inclusion Criteria: * Female patients age between 18-70 year-old, who participate in explor lap gynecological surgery (Hysterectomy, Adnexal surgery and surgical stagings) using general anesthesia technique * American society of Anesthesiologists physical status grade I-II * Capable to communicate in Thai language Exclusion Criteria: * Allergic to NSAIDs and opioid * Allergic to Parecoxib drug * Underlying neuropathic pain * Pregnant woman or woman who undergoes breast feeding * Uncontrolled hypertension disease, BP \>160/110 at admission date * Underlying ischemic heart disease, Ischemic stroke or peripheral arterial disease * History status post coronary artery bypass grafting * Patients who take Aspirin within 7 days before surgery date * Had underlying which is contraindiated to NSAIDs drug such as Gastritis, history of GI ulcer, chronic kidney disease (Cr clearance \< 30ml/min), liver cirrhosis (Child-Pugh class B or above/ serum albumin \< 25 g/l) * Patients who had NSAIDs drug while admit in hospital for preparing the operation before surgery date