CompletedPhase 2

"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"

Egypt45 participantsStarted 2022-01-01

Plain-language summary

The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial. The null hypothesis being tested is that there is no difference in post operative pain between conventional irrigation and the two types of lasers used. Forty-five patients are equally divided into 3 separate groups : * Group A (Conventional): 2.5% NaOCL and 17% EDTA. * Group B(Dual): saline along with Er,Cr:YSGG laser and diode laser combination * Group C(Combined): saline along with 17% EDTA and diode laser combination Each patient is given pain scale chart Numeric Rating Scale (NRS) to record his/her pain level before any endodontic treatment. All data will be collected, tabulated, summarized, and statistically analyzed.

Who can participate

Age range

18 Years – 35 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who had asymptomatic, single-rooted maxillary anterior teeth with necrotic pulp and periapical lesion with a periapical index score of 3 or 4 * Patients complaining of no pain and without fistulous tract * Closed apex. * Acceptance to participate in the study. Exclusion Criteria: * Antibiotic use within the last month, anti-inflammatory analgesic use within the last 5 d, systemic diseases or allergic reactions, calcified canals, root resorption, previous root canal treatment. * Periodontal diseases, presence of swelling or fistulous tract. * Vulnerable group including pregnant females, mentally or physically disabled individuals. - Technical difficulties during root canal treatment such as; curved roots, broken files, over instrumentation, overfilling or incomplete filling.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 6 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 12 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 24 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 48 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 72 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain up to 7 days after intervention in the three groups using NRS

Trial details

NCT IDNCT06129643

SponsorFuture University in Egypt

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-30

View on ClinicalTrials.gov More Pulp Necroses trials

Plain-language summary

Who can participate

Age range

18 Years – 35 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 6 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 12 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 24 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 48 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain 72 hours after intervention in the three groups using NRS

Postoperative pain assessment

Timeframe: Measure changes in post-operative pain up to 7 days after intervention in the three groups using NRS