Ventilation Imaging to Improve the Quality of Life for Patients With Lung Cancer Treated With Rad… (NCT06127654) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Ventilation Imaging to Improve the Quality of Life for Patients With Lung Cancer Treated With Radiation Therapy
Australia165 participantsStarted 2025-05
Plain-language summary
This research project is testing a new treatment planning method for patients with lung cancer who will be treated with radiation therapy. This new method is called Computed Tomography (CT) ventilation imaging. It aims to help protect the healthiest parts of patient's lungs from being injured by the radiation therapy. The investigators will determine whether healthy lung sparing can improve the quality of life in these patients.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Aged 18 years or older.
✓. Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
✓. Stage 3 as determined using the IASLC (International Association for the Study of Lung Cancer) 8th edition lung cancer staging guidelines.
✓. To be treated with curative intent external beam radiotherapy (60 Gy in 30 treatments or 55 Gy in 20 treatments) +/- concurrent chemotherapy and adjuvant PD1/PD-L1 inhibitors.
✓. Whole body Positron Emission Tomography (PET) scan within 8 weeks of registration.
✓. Pulmonary function tests within 8 weeks of registration.
✓. Willingness to give written informed consent.
Exclusion criteria
✕. Serious medical comorbidities that may contraindicate curative radiotherapy.
✕. Inability to attend full course of radiotherapy or follow-up visits.
✕. A current or former diagnosis of interstitial lung disease.
✕. Prior history of lung cancer within 5 years.
✕. Prior thoracic radiotherapy at any time.
What they're measuring
1
Patients receiving healthy lung sparing treatment (interventional arm) have better quality of life than patients receiving standard treatment (control arm).