RecruitingNot Applicable

Exercise and Emotional Learning in Posttraumatic Stress Disorder

United States100 participantsStarted 2024-05-13

Plain-language summary

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

Who can participate

Age range18 Years – 64 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults with PTSD related to interpersonal violence Exclusion Criteria: * Active or recent (within the last 3 months) severe substance use disorder(s) * Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes * Significant developmental disabilities * Current daily benzodiazepine or stimulant use with inability to abstain for study sessions * Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks) * Medical condition(s) that prohibit exercise * History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins * Magnetic resonance imaging (MRI) contraindication(s) * Positive pregnancy test * History of seizure disorder * Spontaneous seizure(s) within the last 3 months

What they're measuring

Change in participant subjective emotional ratings

Timeframe: 24 hours

Change in Heart Rate

Timeframe: 24 hours

Change in Fear Circuit Blood Oxygen Level-Dependent (BOLD) Response

Timeframe: 48 hours

Trial details

NCT IDNCT06127342

SponsorChristal L Badour

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-30

Contact for this trial

Christal G Badour, PhD

859-323-3817 christal.badour@uky.edu