Influence of Kinesiophobia on the Excitability of Connections Parieto-frontal During a Pointing M… (NCT06125613) | Clinical Trial Compass
CompletedNot Applicable
Influence of Kinesiophobia on the Excitability of Connections Parieto-frontal During a Pointing Movement in Humans
France24 participantsStarted 2021-12-10
Plain-language summary
Objective(s) of the trial: Better understand the interaction between kinesiophobia and motor control. Main objective: To measure the influence of induced kinesiophobia on functional connectivity between the posterior parieto-occipital region and the primary motor cortex in healthy subjects during a pointing task.
Secondary objectives: The secondary objectives will be 1) to verify the excitatory influence of pIPS stimulation on the excitability of M1 at rest and 2) to establish whether there is a correlation between functional connectivity and the level of kinesiophobia ( as measured by the Tampa Scale)
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult men and women
* Healthy subjects (who do not have self-reported neurological disorders)
* Subjects having signed informed consent (having a good command of French)
* Subjects affiliated or beneficiaries of a social security system
Exclusion Criteria:
* Psychiatric history obtained by questioning the doctor: people with mental retardation or severe impairment of cognitive, behavioral or affective functions prevents understanding the protocol and signing the informed consent
* Neurological history (epilepsy, stroke, operations performed on the brain or spinal cord and history of neurological diseases affecting motor skills and sensitivity)
* Subjects for whom we are unable to receive informed information (dementia, hearing problems, insufficient mastery of French etc.)
* Contraindications to TMS (epilepsy, intracranial metallic foreign bodies, hearing aids or cochlear implants)
* Taking psychotropic medications
* Persons under guardianship or curatorship
* Pregnant and breastfeeding women
* Subjects with a cardiac pacemaker
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Influence of induced kinesiophobia on the functional connectivity between the posterior parieto-occipital region and the primary motor cortex in healthy subjects during a pointing task.