UnknownNot Applicable

Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian Failure

China100 participantsStarted 2023-01-01

Plain-language summary

The purpose of this study is to investigate the brain MRI imaging changes and associated factors on cognition function in patients with premature ovarian failure.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. Subjects must meet all the following criteria to be included in the study:
✓. Female, between 18 and 40 years old;
✓. FSH ≥ 40U/L on two occasions at least four weeks;
✓. Sign informed consent. 2. Criteria for the health control group: According to the case control principle, at the same time, the investigators select women with similar age, BMI, working environment, education level and regular menstrual cycle in our hospital, and conduct endocrine examination (FSH \<10U/L) for health examination.

Exclusion criteria

✕. Pregnancy or lactation;
✕. Patients with secondary ovarian insufficiency (such as causes of the hypothalamus);
✕. Chromosomal karyotype abnormalities (such as Turner syndrome, brittle X syndrome);
✕. Any disease that requires immediate blood transfusion;
✕. Abuse of alcohol, drugs or drugs (for example, laxatives)
✕. Allergies to MRI contrast agents;
✕. Accompanied by metal implants, claustrophobia and other magnetic resonance scanning contraindications;
✕. Accompanied by serious brain organic diseases, such as epilepsy, stroke, encephalitis, brain trauma, and so on. Nervous system diseases, such as Parkinson's disease, have other cognitive-impacting diseases, or serious somatic diseases such as malignant tumors, acute heart failure, multi-organ failure, and so on.

What they're measuring

Brain structure

Timeframe: 1 year

Trial details

NCT IDNCT06121388

SponsorInternational Peace Maternity and Child Health Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-01

Contact for this trial

Dongmei Lai, M.D.

86-021-64070434 laidongmei@hotmail.com

View on ClinicalTrials.gov More Premature Ovarian Failure trials