RecruitingNot Applicable

Effect of Visual Retraining After Stroke

United States100 participantsStarted 2024-09-05

Plain-language summary

This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.

Who can participate

Age range

21 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Cortically Blind Subjects Inclusion: * Between 21 and 80 years of age * Residents of the United States or Canada * Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years) * Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus. * Able to fixate on visual targets reliably for 1000ms * Must have a home computer (desktop or laptop) and reliable internet access * Willing, able, and competent to provide informed consent * Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months. Exclusion: * Past or present eye disease interfering with visual acuity * BCVA worse than 20/40 in either eye * Damage to the dorsal Lateral Geniculate Nucleus * Diffuse whole brain degenerative processes * History of traumatic brain injury * Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures * Documented history of drug/alcohol abuse * Currently taking neuroactive medications which would impact training, as determined by PI * Presence of cognitive or seizure disorders * One-sided attentional neglect * Subjects who lack the competence or are otherwise unable to p…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Mean Direction Discrimination Threshold

Timeframe: Baseline to 4-6 months

Change in Mean Direction Discrimination Threshold

Timeframe: Baseline to 8-12 months

Change in Mean Direction Integration Threshold

Timeframe: Baseline to 4-6 months

Change in Mean Direction Integration Threshold

Timeframe: Baseline to 8-12 months

Change in Mean Contrast Sensitivity for Direction

Timeframe: Baseline to 4-6 months

Change in Mean Contrast Sensitivity for Direction

Timeframe: Baseline to 8-12 months

Change in Mean Contrast Sensitivity for Static Orientation

Timeframe: Baseline to 4-6 months

Trial details

NCT IDNCT06121219

SponsorUniversity of Rochester

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-01

Contact for this trial

Evan Burr

585-275-5234 Evan_Burr@urmc.rochester.edu

View on ClinicalTrials.gov More Vision Loss Partial trials

Plain-language summary

Who can participate

Age range

21 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Mean Direction Discrimination Threshold

Timeframe: Baseline to 4-6 months

Change in Mean Direction Discrimination Threshold

Timeframe: Baseline to 8-12 months

Change in Mean Direction Integration Threshold

Timeframe: Baseline to 4-6 months

Change in Mean Direction Integration Threshold

Timeframe: Baseline to 8-12 months

Change in Mean Contrast Sensitivity for Direction

Timeframe: Baseline to 4-6 months

Change in Mean Contrast Sensitivity for Direction

Timeframe: Baseline to 8-12 months

Change in Mean Contrast Sensitivity for Static Orientation

Timeframe: Baseline to 4-6 months