Hyper-Spectral Endoscopy for Detection of Early Neoplasia in Barrett's Oesophagus

Inclusion Criteria: * Male or female subjects over 18 years. * Previous diagnosis of Barrett's oesophagus, with an endoscopic length of at least 2 cm if circumferential (C≥2 according to Prague classification) or 3 cm if not circumferential (maximal extent M≥3, according to Prague classification). * Previous diagnosis of oesophageal glandular dysplasia or early oesophageal adenocarcinoma for consideration of endoscopic therapy. Exclusion Criteria: * History of oesophageal stricture precluding passage of the endoscope. * Pregnancy, or planned pregnancy during the course of the study. * Currently breastfeeding. * Any history of oesophageal varices, liver impairment of moderate or worse severity (Child's- Pugh class B \& C) or evidence of varices on initial treatment endoscopy. * Any history of oesophageal surgery, except for uncomplicated fundoplication. * History of coagulopathy, with INR\>1.3 and/or platelet count of \<75,000. * On clopidogrel, and/or warfarin for high risk condition and unable to withhold temporarily the medication.