Probiotics For The Prevention of Antibiotics Associated Diarrhea in the Pediatric Intensive Care Unit

Inclusion Criteria: * Admitted to PICU * Requiring \> 72 hrs of antibiotic therapy * \< 17 years * Able to administer oral LGG or placebo Exclusion Criteria: * Antibiotics 48 hours prior to hospital admission * Probiotic use within 7 days of admission * Pre-existing diarrhea at time of hospital admission or 24 hours prior to admission * Laxative therapy at time of admission or 48 hours prior to admission * HIV with CD4 \< 250 * Established immunologic deficiencies (ANC \< 100) * Chronic steroid therapy ( \> 10 days) * GI disorders including intussusception, lower bowel disease, bowel resection, irritable bowel syndrome, ulcerative colitis, or Crohn's disease * Status post-surgical patients with antibiotic prophylaxis (\< 72 hours duration) * NPO