Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion

Inclusion Criteria: * Adults ≥18 years of age. * Willing to provide written informed consent. * Documented history of T2D * No documented history of diabetes Exclusion Criteria: * Unable or unwilling to provide written informed consent or provide a peripheral blood sample. * Any life-threatening disease expected to result in death within two years of consent. * Any malignancy not considered cured (except basal cell carcinoma of the skin). An individual is considered cured if there has been no evidence of cancer recurrence for the five years prior to screening. * Known severe liver disease. * White blood cell count ≥15 x 10\^9/L. * Active infectious disease requiring systemic antibiotic or anti-viral agents. * Known acquired immunodeficiency syndrome such as HIV. * Treated autoimmune disorders (e.g. T1D and LADA). * On oral steroid therapy (e.g. prednisone or other corticosteroids) or other immunosuppressive agents (e.g. methotrexate).