TerminatedNot Applicable

Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure

Stopped: Difficulty in recruiting subjects due to a variety of factors beyond our control.

United States50 participantsStarted 2024-04-03

Plain-language summary

The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.

Who can participate

Age range21 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * admission diagnosis of hypercapnic respiratory failure * pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample. Exclusion Criteria: * age \<21 * Pregnant * Inmate/Prisoner * Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery) * Chest wall defect, neuromuscular disease or diaphragmatic paralysis. * BMI \>50

What they're measuring

Resolution of Hypercapnic Respiratory Failure

Timeframe: 1-3 days

Trial details

NCT IDNCT06108284

SponsorUniversity of Missouri-Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-21

View on ClinicalTrials.gov More Acute Hypercapnic Respiratory Failure trials