Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on Knee Joint

Inclusion criteria * Symmetrical mild-to-moderate chronic plaque psoriasis * Chronic stable plaque psoriasis * Bilateral lesions of approximately 25 cm² * Had not been receiving any treatment for at least one month. * Those with infection or malignancy and/or subjects who had undergone major surgery in the past 6 months were not included in the study. * Patients that had not undergone systemic treatment for psoriasis during the previous 3 months were included in the study * age 20 - 50 with mild to moderate knee plaque psoriasis * Symmetrical plaque psoriasis * PASI score affected \< 20 * BSA of knee involvement : 2% to 20% Exclusion criteria * Patients with malignant tumors, those diagnosed with psoriatic arthritis or any other systemic inflammatory disease, or those using medication were excluded from the study. * Pregnancy * Receiving steroid preparations * topical or UVB therapy within previous 4 wks * Systemic corticosteroids, PUVA, or laser phototherapy within previous 4 wks * Other systemic therapies or biologicals within previous 3 wks * Widespread psoriasis * Hypercalcaemia * Liver or renal disease