CompletedNot Applicable

Respiratory Muscle Assesment in COVID-patients Without Hospitalization

Germany25 participantsStarted 2024-12-01

Plain-language summary

Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory physiology laboratory in patients who were not hospitalized during the acute COVID-19-infection but still complain of different persistent symptoms including exertional dyspnea and fatigue.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion Criteria: * Patients with COVID-19 infection without hospitalization during the acute infection (n=25) * Patients aged at least 18 years, who are mentally and physically able to consent and participate into the study Exclusion Criteria: * Clinically pre-established cardiovascular disease or other pulmonary diseases which might lead to exertional dyspnea (systolic heart failure, COPD). * Body-mass-index (BMI) \>40 * Expected absence of active participation of the patient in study-related measurements * Alcohol or drug abuse * Metal implant in the body that is not MRI compatible (NON MRI compatible pacemaker, implantable defibrillator, cervical implants, e.g. brain pacemakers etc.) * Slipped disc * Epilepsy * Bound to a wheel chair

What they're measuring

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots

Timeframe: 1 year

Respiratory mouth pressures

Timeframe: 1 year

Trial details

NCT IDNCT06105450

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-01

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