RecruitingNot Applicable

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

United States150 participantsStarted 2024-12-05

Plain-language summary

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy individuals aged 18 to 65 * BMI of 20-35.0 kg/m2 * Normal or corrected-to-normal vision * Good general health * Ability to understand and willingness to sign written informed consent document Exclusion Criteria: * Current and/or past medical conditions * Current and/or past eating disorder * On a restricted diet and/or taking weight loss medication(s) * History of bariatric surgery * Weight fluctuation \>3% in past 3 months * Recent history of illicit recreational drug abuse * Current nicotine use * Intellectual disability * Conditions that might result in increased risks of side effects or complications from TMS or MRI

What they're measuring

Change in BOLD response in the cerebellum

Timeframe: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)

Change in BOLD response in the ventral striatum

Timeframe: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)

Change in food reward valuation

Timeframe: up to 60 minutes pre-TMS and up to 60 minutes post-TMS, at each of two main study visits (fed, fasted)

Ad libitum snack food intake

Timeframe: baseline, up to 60 minutes post-TMS at each of two main study visits (fed, fasted)

Trial details

NCT IDNCT06105164

SponsorBrigham and Women's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-08

Contact for this trial

Laura Holsen, PhD

617-525-8772 lholsen@bwh.harvard.edu

View on ClinicalTrials.gov More Appetitive Behavior trials

Plain-language summary

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in BOLD response in the cerebellum

Timeframe: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)

Change in BOLD response in the ventral striatum

Timeframe: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)

Change in food reward valuation

Timeframe: up to 60 minutes pre-TMS and up to 60 minutes post-TMS, at each of two main study visits (fed, fasted)

Ad libitum snack food intake

Timeframe: baseline, up to 60 minutes post-TMS at each of two main study visits (fed, fasted)