CompletedNot Applicable

Indicator Amino Acid Oxidation in ICU Patients

Netherlands8 participantsStarted 2023-10-30

Plain-language summary

This study will use the indicator amino acid oxidation technique (IAAO) to determine protein oxidation of ICU patients at two protein intakes: 1.3 g/kg/d versus 2.0 g/kg/d.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ≥ 18 years old * Unplanned admission to the ICU * Mechanically ventilated * Start of enteral nutrition within 2 days of intubation * ≥ 3 days on enteral nutrition * Expected remaining ICU stay on mechanical ventilation of ≥ 2 days Exclusion Criteria: * Contra-indication for enteral nutrition at the discretion of the treating physician * Feeding intolerance during incremental feeding protocol * Moribund or withholding of treatment * On extracorporeal membrane oxygenation (ECMO) * Presence of chest drains, pneumothorax, tracheoesophageal fistula or subcutaneous emphysema * Kidney failure AND a "no dialysis"-code on admission * Hepatic encephalopathy (West Haven criteria 3-4) * BMI \< 18 kg/m2

What they're measuring

Indicator amino acid oxidation

Timeframe: Collected at standard vs higher protein administration, on test day 1 and 2 (depending on randomisation order), during the first week of ICU admission.

Trial details

NCT IDNCT06104527

SponsorMaastricht University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-23

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