Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients

Inclusion Criteria: * Adult female patients who were seeking for orthodontic treatment with controlled previous chronic periodontitis. * Pocket depth of more than 5 mm before receiving non-surgical periodontal treatment or/and Pocket depth of less than 4 mm after periodontal therapy. * Sever to very sever irregularity of mandibular anterior arch according to Little's irregularity index ranging from 7 to 10 mm with acceptable oral hygiene. * all the permanent dentition excluding third molars should be present. * No systemic disease or history of prolonged use of medication interfering with tooth movement as corticosteroids. Exclusion Criteria: * Previous orthodontic treatment. * Patients with aggressive periodontitis or Any smoking habits. * Pregnant or lactating female patients were excluded.