RecruitingNot Applicable

The Correlation Between Ovarian Function and Serum Biomarkers

China35 participantsStarted 2023-10-25

Plain-language summary

The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.

Who can participate

Age range

18 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. The selection criteria for healthy individuals are follows.
. The selection criteria for DOR patients are follows.
. Selection criteria for POI patients are follows.

Exclusion criteria

. Patients with congenital gonadal developmental abnormalities or a family history similar to "early menopause".
. Patients with acquired organic lesions or decreased ovarian function caused by ovarian surgery.
. Patients who have undergone artificial cycle therapy with Western medicine or other endocrine treatments within the past three months.
. Patients with severe primary diseases and mental disorders such as crdiovascular, cerebrovascular, liver, kidney, and hematopoietic system.
. Patients during lactation or pregnancy.
. Patients who are allergic to the drugs used in this study or have a history of allergic reactions to traditional Chinese medicine.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

copper

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

Iron ion

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

ceruloplasmin, CP

Timeframe: On the 2~4th day of menstruation (amenorrhea patientson the enrolled week)

CuZn-Superoxide Dismutase, CuZn-SOD/SOD1

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

Malondialdehyde，MDA

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

Trial details

NCT IDNCT06096766

SponsorShi Yun

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-11-11

Contact for this trial

Yun Shi, PhD

13717926522 zysyun@163.com

View on ClinicalTrials.gov More Premature Ovarian Insufficiency trials

Who can participate

Age range

18 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. The selection criteria for healthy individuals are follows.
. The selection criteria for DOR patients are follows.
. Selection criteria for POI patients are follows.

Exclusion criteria

. Patients with congenital gonadal developmental abnormalities or a family history similar to "early menopause".
. Patients with acquired organic lesions or decreased ovarian function caused by ovarian surgery.
. Patients who have undergone artificial cycle therapy with Western medicine or other endocrine treatments within the past three months.
. Patients with severe primary diseases and mental disorders such as crdiovascular, cerebrovascular, liver, kidney, and hematopoietic system.
. Patients during lactation or pregnancy.
. Patients who are allergic to the drugs used in this study or have a history of allergic reactions to traditional Chinese medicine.

What they're measuring

copper

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

Iron ion

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

ceruloplasmin, CP

Timeframe: On the 2~4th day of menstruation (amenorrhea patientson the enrolled week)

CuZn-Superoxide Dismutase, CuZn-SOD/SOD1

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)

Malondialdehyde，MDA

Timeframe: On the 2~4th day of menstruation (amenorrhea patients on the enrolled week)