Study Comparing Platelet Transfusion Volumes in Premature Babies

Inclusion Criteria: * Infants born at or before 32+0 weeks' gestation or less than 1500g at birth * Written informed consent obtained from parent * Admission to a participating NICU (includes postnatal transfers) * Severe Thrombocytopenia (platelet count \<25 x109/L) * Cranial ultrasound scan undertaken less than 24 hours prior to randomisation shows no recent major intraventricular haemorrhage (IVH) or significant extension of previous haemorrhage. Exclusion Criteria: * Major congenital anomalies including neural tube defects, major structural cardiac anomalies (excluding PDA/ASD/VSD), abdominal wall defects and congenital diaphragmatic hernia and major dysmorphic features with an abnormal karyotype e.g., T21, T13, T18, Fanconi's anaemia, Thrombo-cytopenia Absent Radius syndrome). * Infants on a palliative care pathway * Neonates within 72 hours of major bleed * All fetal intracranial haemorrhages excluding subependymal haemorrhage from any antenatal ultrasound scan. * Known immune thrombocytopenia or family history of allo-immune thrombocytopenia or maternal anti platelet antibodies or maternal idiopathic thrombocytopenic purpura * Neonates who did not receive parenteral vitamin K