Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response In… (NCT06091631) | Clinical Trial Compass
CompletedNot Applicable
Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation
Egypt100 participantsStarted 2023-11-15
Plain-language summary
Magnesium sulfate has many mechanisms of action for attenuating the stress response as inhibition of catecholamine releasing from the adrenal medulla, keeping the plasma concentration of epinephrine at a fixed level, decreasing the circulating norepinephrine level when compared to that of a control group\[ and also has a vasodilation effect on systemic and coronary blood vessels by blocking calcium ion in vascular smooth muscle.-Methyl- D-Aspartate (NMDA) antagonism is an amazing recent discovery for magnesium sulphate to play an important role in stress response.
In this study, we will study the effects of nebulized magnesium sulfate on hemodynamics during intubation.
Who can participate
Age range
20 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 20-50 years old
* ASA: 1, 2
* Elective fit laparoscopic cholecystectomy
Exclusion Criteria:
* -Patient refusal
* patients with history of hypersensitivity to magnesium sulphate
* patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure
* on beta blockers or calcium channel blockers
* expected difficult intubation (Mallampati 4)
* Body mass index \> 40
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of post-operative sore throat at 0 hours in both groups
Timeframe: at 0 hours in both groups
2
Incidence of post-operative sore throat at 2 hours in both groups
Timeframe: at 2 hours in both groups
3
Incidence of post-operative sore throat at 4 hours in both groups
Timeframe: at 4 hours in both groups
4
Incidence of post-operative sore throat at 24 hours in both groups