CompletedNot Applicable

STN-DBS and the Risk of Sialorrhea

China234 participantsStarted 2019-01-01

Plain-language summary

OBJECTIVE: The aims of this study were to assess the incidence rate and risk factors for sialorrhea in the long-term follow-up in a cohort of 170 patients with advanced Parkinson's disease \[84 with deep brain stimulation (DBS) and 86 on medical treatment\]. Design, setting, and participants: This study was a multi-center prospective non-randomized concurrent clinical trial. A total of198 persons with Parkinson disease were referred for DBS between June 2019 and July 2021 and analyzed between June 2023 and July 2023.The primary outcome follow-up visit was conducted 36 months after DBS.

Who can participate

Age range20 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of Alzheimer's Disease * Age between 20 and 80 years * without drooling * swallowing function \<5 on the Drooling Rate Scale (DRS). * Medications affecting drooling had to have stopped medications at least 4 weeks before study entry. Exclusion Criteria: * Not he typical PD * Subjects on warfarin, * with significant medical illnesses or neuromuscular transmission disorders * past use of BoNT * -cognitive impairment (\<23/30 on Mini Mental Status Exam) were excluded.

What they're measuring

DRS score 36 months postoperatively

Timeframe: 36 months after STN-DBS

Trial details

NCT IDNCT06090929

SponsorQilu Hospital of Shandong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-01-01

View on ClinicalTrials.gov More Parkinson Disease trials