The goal of this observational study is to assess movement in individuals with Myotonic Dystrophy Type 1 (DM1) and Type 2 (DM2) using digital biomarker tools. The long-term aim of this study is to incorporate these outcomes into clinical trials of DM1 and DM2 therapies. Participants will complete a series of assessments that allow for researchers to measure hand myotonia and walking quality, including a Video Hand Opening Test (VHOT), grip strength, 10 meter walk/run test, 6 minute walk test, Timed Up and Go (TUG), Motor Function Measures-32 (MFM-32) test, and more. These assessments may be recorded to detect and map participants motion and walking patterns. Several patient reported outcome (PROs) questionnaires will also be recorded. Participants may also be asked to monitor exercise and sleep activity at home using an Actigraph wearable device. This study is divided into 2 parts: Part A consists of a single visit. Part B consists of a 1-year longitudinal study with 3 clinical follow-up visits.
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Video Hand Opening Time (VHOT)
Timeframe: Baseline through month 12
Grip Strength
Timeframe: Baseline through month 12
Motor Function Measures (MFM-32)
Timeframe: Baseline through month 12
10 Meter Walk/Run Test
Timeframe: Baseline through month 12
6 Minute Walk Test
Timeframe: Baseline through month 12
Timed Up and Go (TUG)
Timeframe: Baseline through month 12
Time to Ascend and Descend 4 Stairs
Timeframe: Baseline through month 12
Timed Supine to Sit
Timeframe: Baseline through month 12
Step Test
Timeframe: Baseline through month 12
Walk-12 Questionnaire
Timeframe: Baseline through month 12
DM-ACTIVE Questionnaire
Timeframe: Baseline through month 12
The Physical Activity Disability Scale (PADS-R)
Timeframe: Baseline through month 12