RecruitingNot Applicable

Speech-in-noise Perception in Autism and Fragile X

United States60 participantsStarted 2023-11-10

Plain-language summary

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Who can participate

Age range15 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. normal audiograms (PTA ≤ 20 dB HL)
✓. corrected 20/20 vision (Snellen chart)
✓. no history of premature birth (prior to 36 weeks gestation)
✓. no medications known to affect EEG signal
✓. English as the first language
✓. Documented PCR/Southern Blot genetic testing confirming full mutation FXS
✓. Diagnosis of Autism Spectrum Disorder, per Autism group.
✓. no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome

What they're measuring

Speech reception threshold for single digits in noise- auditory only

Timeframe: Baseline

Speech reception threshold for single digits in noise- with visual stimuli

Timeframe: Baseline

Scaled score for auditory attention subtest

Timeframe: Baseline

correlation between neural activation to speech (fNIRS) and neural differentiation of speech-in-noise (ERP)

Timeframe: Baseline

correlation between neural activation to background noise (fNIRS) and neural differentiation of speech-in-noise (ERP)

Timeframe: Baseline

Sensory Profile 2

Timeframe: Baseline/before baseline

Sensory Experiences Questionnaire (SEQ)

Timeframe: Baseline/before baseline

Sensory Perception Quotient

Timeframe: Baseline/before baseline

Trial details

NCT IDNCT06088589

SponsorChildren's Hospital Medical Center, Cincinnati

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-30

Contact for this trial

Elizabeth Smith, PhD

513-517-1383 elizabeth.smith3@cchmc.org

View on ClinicalTrials.gov More Autism Spectrum Disorder trials

Plain-language summary

Who can participate

Age range15 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. normal audiograms (PTA ≤ 20 dB HL)
✓. corrected 20/20 vision (Snellen chart)
✓. no history of premature birth (prior to 36 weeks gestation)
✓. no medications known to affect EEG signal
✓. English as the first language
✓. Documented PCR/Southern Blot genetic testing confirming full mutation FXS
✓. Diagnosis of Autism Spectrum Disorder, per Autism group.
✓. no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome

What they're measuring

Speech reception threshold for single digits in noise- auditory only

Timeframe: Baseline

Speech reception threshold for single digits in noise- with visual stimuli

Timeframe: Baseline

Scaled score for auditory attention subtest

Timeframe: Baseline

correlation between neural activation to speech (fNIRS) and neural differentiation of speech-in-noise (ERP)

Timeframe: Baseline

correlation between neural activation to background noise (fNIRS) and neural differentiation of speech-in-noise (ERP)

Timeframe: Baseline

Sensory Profile 2

Timeframe: Baseline/before baseline

Sensory Experiences Questionnaire (SEQ)

Timeframe: Baseline/before baseline

Sensory Perception Quotient

Timeframe: Baseline/before baseline