CompletedNot Applicable

Low vs. Air Oxygen Concentration CAPA-IVM Culture of Cumulus-oocyte Complexes

Vietnam20 participantsStarted 2023-11-09

Plain-language summary

IVM with a pre-maturation step, known as capacitation IVM (CAPA-IVM), has demonstrated enhanced maturation of human oocytes in vitro and successful live births. However, CAPA-IVM has shown lower rates of embryo formation when compared to conventional in vitro fertilization/ intra cytoplasmic sperm injection (IVF/ICSI) cycles. To optimize the CAPA-IVM culture system, this pilot study aims to evaluate the impact of low oxygen versus air oxygen concentrations on embryological outcomes in PCOS patients.

Who can participate

Age range18 Years – 37 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ≤38 years * Having polycystic ovarian morphology: at least 25 follicles (2-9 mm) throughout the whole ovary and/or increased ovarian volume (\>10ml) * Having at least 20 follicles on the Oocyte Pick-up day * Patients consent to culture embryos to the blastocyst Exclusion Criteria: * Cases with severe male factor (concentration \<5 million/ml, cryptozoospermia, azoospermia) * Oocyte donation * Pre-implantation genetic testing

What they're measuring

Number of blastocyst

Timeframe: At least 5 days after intra-cytoplasmic sperm injection

Trial details

NCT IDNCT06087354

SponsorMỹ Đức Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-30

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