CompletedPhase 2

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

United States46 participantsStarted 2023-12-05

Plain-language summary

Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use. The purpose of the present study is to see how well nicotine patches and lozenges help people quit both smoking and vaping, and to determine if higher doses of the medication work best.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18yrs + * Daily nicotine-containing e-cigarette user (25+ days per previous month) * E-cigarette use 5+ times/day * E-cigarette use \> 1year * Smoking \>1 cigarette on 5-7 days per week * Interest in quitting smoking and e-cigarette within the next month (\>7 on 10-point scale) * Willingness to use NRT * Able to receive text messages/email * Mailing address in South Carolina. Exclusion Criteria: * Medical conditions contraindicated to NRT use (including pregnancy, past month myocardial infarction, current cardiac arrhythmia, current angina, uncontrolled vascular disease, or medical conditions in which consumption of phenylalanine is contraindicated) * Individuals reporting current use of other nicotine-containing products and/or smoking cessation medications * Those who vape non-nicotine substances * Individuals unable to consent (e.g. significant cognitive deficit, non-English speaking).

What they're measuring

Days of Dual Use Abstinence

Timeframe: Day 28, Day 56

Trial details

NCT IDNCT06087328

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-11-05

Results submitted2025-10-02

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