Effects of Immunonutrition on the Improvement of Postoperative Adjuvant Chemotherapy Related Adve… (NCT06085365) | Clinical Trial Compass
UnknownPhase 3
Effects of Immunonutrition on the Improvement of Postoperative Adjuvant Chemotherapy Related Adverse Reactions in Patients With Gastrointestinal Tumors
China324 participantsStarted 2023-07-24
Plain-language summary
Evaluate the effects of Suyusu (immunonutrition) in postoperative adjuvant chemotherapy for gastrointestinal cancer patients. The main endpoint of the study was the incidence of chemotherapy related adverse reactions (including bone marrow suppression, nausea and vomiting, diarrhea, and mucositis) in patients after two cycles of chemotherapy. The secondary endpoint indicators were: quality of life score (EORTC-QLQ-C30), nutritional risk score (PG-SGA, NRS2002), nutritional assessment indicators, changes in immune microenvironment, analysis of psychological status, survival time (1-year progression free survival rate), treatment tolerance (dose intensity, rate of treatment interruption, delay), etc.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Subjects voluntarily and sign an informed consent form;
✓. Age ≥ 18 years old and ≤ 75 years old;
✓. Patients with stage II-III gastrointestinal malignancies with clear pathological diagnosis and undergoing radical surgery
✓. No adjuvant chemotherapy received after surgery
✓. The Eastern Cancer Collaborative Group's Physical State Score (ECOG) is 0-2 points;
✓. No contraindications to chemotherapy and the use of fluorouracil based chemotherapy regimens;
Exclusion criteria
✕. Allergy to the components of immune nutrients, allergic constitution, or other inability to eat;
✕. Participated in other drug or food clinical trials within 2 months prior to enrollment;
✕. Having a history of immune deficiency, including HIV testing positive, or having other acquired or congenital immune deficiency diseases, or having a history of organ transplantation, or active infections that are not suitable for chemotherapy (as determined by the researcher);
What they're measuring
1
the incidence of chemotherapy related adverse reactions
Timeframe: the first two cycles of chemotherapy. (each cycle is 21 ± 3 days)