UnknownPhase 1/2

Evaluation of Topical Rebamipide Versus Topical Betamethasone for Management of Oral Ulcers in Behcet's Disease

40 participantsStarted 2023-12

Plain-language summary

The goal of this randomized clinical trial is to to compare the effect of topical rebamipide to topical betamethasone on oral ulcer severity in patients with Behcet's disease.. The main question it aims to answer is : What is the effect of topical Rebamipide mouthwash compared to topical betamethasone mouthwash in management of oral ulcers in Behcet's disease? Participants will will be divided randomly into the two groups and the following outcomes will be measured: The oral ulcers severity Pain associated with oral ulcers Number of oral ulcers Healing time of oral ulcers

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. Patients diagnosed with Behcet's disease as defined by the revised International Criteria for Behcet's Disease (ICBD2014).
✓. Patients with active oral ulcers.
✓. Patients free from any visible oral lesions other than the oral ulcers of BD.
✓. Patient who will agree to participate in the study and take the supplied interventions.

Exclusion criteria

✕. Patients with history of a severe or chronic medical condition including congestive heart failure, malignancy and active infection including tuberculosis, hepatitis and human immunodeficiency virus.
✕. Patients who refuse to sign the informed consent.

What they're measuring

oral ulcer severity

Timeframe: During the first week (days 1, 3, and 7), then every week for 3 weeks, afterward every month for 2 months.

Trial details

NCT IDNCT06084624

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01

View on ClinicalTrials.gov More Oral Ulceration Due to Behçet's Disease trials