RecruitingPhase 2/3

Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia

Denmark32 participantsStarted 2023-12-20

Plain-language summary

The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI).
✓. Scheduled for elective supratentorial craniotomy.
✓. Patients aged between 18 and 75 years.
✓. American Society of Anesthesiologists status 1-3

Exclusion criteria

✕. History of allergy or intolerance to one of the study medications.
✕. Active treatment with monoamine oxidase inhibitors.
✕. An American Society of Anesthesiologists (ASA)physical status IV-VI.
✕. Pregnancy or breastfeeding.
✕. Inability to provide written informed consent -

What they're measuring

Cerebral blood flow

Timeframe: Up to 3 hours (measured on the day of surgery prior to the surgical procedure)

Trial details

NCT IDNCT06083948

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-30

Contact for this trial

Rasmussen

004529265713 mads.rasmussen@vest.rm.dk

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