The goal of this clinical trial is to study and describe the effects of bilateral tDCS applied to dorso-lateral-prefrontal cortex (DLPC) in patients with drug-resistant migraine in terms of reduction in frequency of pain, impact of pain in daily life, quality of sleep and psychological measures. We finally planned to include high frequency and chronic migraine patients. The main questions it aims to answer are: * Will bilateral DLPC tDCS be feasible, well tolerated and safe in drug resistant migraine patients? * Will bilateral DLPC tDCS be effective in reducing pain frequency, intensity and its impact in daily life activities? * Will bilateral DLPC tDCS be effective in ameliorating sleep and psychological associated symptoms? * Will bilateral DLPC tDCS be such effective in reducing pain frequency, intensity and its impact in daily life activities as anti-CGRP treatments? Participants will undergo 2 tDCS sessions daily for 2 consecutive weeks. Patients will be blinded to treatment and will be divided in two groups (real vs placebo). A third group of patients, age-matched to the other two, will undergo anti-CGRP treatment. Patients will be asked to complete Patient-Reported Outcomes (PROMs) scales at baseline, one week after the end of the treatment and at 6 months after the end of the treatment. Researchers (blinded to the treatment) will compare the group that underwent real tDCS treatment vs the one that underwent placebo tDCS vs the one that underwent anti-CGRP drugs to see if bilateral DLPC tDCS is effective in reducing migraine frequency, intensity and impact and if bilateral DLPC tDCS is such effective as anti-CGRP treatment.
Age range
18 Years – 80 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Migraine attacks monthly frequency
Timeframe: baseline, 2 weeks after the end of the treatment, 6 months
Headache Impact Test (HIT-6) score
Timeframe: baseline, 2 weeks after the end of the treatment, 6 months
Pain killer drugs monthly taken
Timeframe: baseline, 2 weeks after the end of the treatment, 6 months