This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which one is the control group. Children's immune responses to live oral rotavirus vaccine as well as conventional vaccinations given at three, five and 12 months old will be determined by measuring salivary and serologic responses. Responses will be compared between the four groups. Stool samples will also be collected from participants and the composition of the microbiome compared between the four groups.
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Serum antibody response to rotavirus
Timeframe: 2 years
Salivary antibody response to rotavirus
Timeframe: 2 years
Serum antibody response to other microbes
Timeframe: 2 years
Salivary antibody response to other microbes
Timeframe: 2 years