A Combined Biomarker Model for Risk Stratification of Indeterminate Pulmonary Nodules

Inclusion Criteria: * Adults \> 21 y/o * IPNs 8-30mm referred for evaluation Figure 4. AUC and reclassification of Combined Biomarker Model * Intermediate risk IPN defined as 10-70% risk after applying Mayo risk predictor model * Solid nodules or part-solid nodules with solid component \>=8mm * CT scan with nodule of concern performed within 60 days of enrollment Exclusion Criteria: Pure ground glass nodule or subsolid nodule with solid component \<8mm * Currently on therapy for any cancer * History of primary lung cancer within the last 5 years * Multiple nodules highly suspicious for metastatic disease * Other malignancy within the last 2 year - Excluding skin cancer other than melanoma * Pregnant women * Prisoners * Inability to provide informed consent * Serologic evidence of active fungal infection