Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention (NCT06073106) | Clinical Trial Compass
RecruitingNot Applicable
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
Singapore500 participantsStarted 2025-01-01
Plain-language summary
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty.
In this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.
Who can participate
Age range50 Years
SexALL
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Inclusion criteria
✓. Age ≥ 50y
✓. Asian ethnicity
✓. First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)
✓. Living in community
✓. Able to understand 1 step simple commands
✓. For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission
✓. For outpatients: (i) \>6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking.
Exclusion criteria
✕. Nursing home or dormitory resident
✕. Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)
✕. Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,
✕. Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium
✕. Anticipated life expectancy \< 1 year
✕
What they're measuring
1
Incidence (rates) of Frailty
Timeframe: Through study's data collection period, up to 4 years
2
Severity of Frailty
Timeframe: For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient: Visit 1 (baseline) to Visit 4 (end of 3rd year)