CompletedPhase 1

The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles

Egypt80 participantsStarted 2023-01-10

Plain-language summary

Objective: this study aimed to evaluate the therapeutic effects of topical application of miconazole and miconazole-loaded chitosan nanoparticles in treatment diabetic patients with oral candidiasis.

Who can participate

Age range30 Years – 65 Years

SexALL

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Inclusion criteria

✓. uncontrolled diabetes patients with oral candidiasis and their uncontrolled diabetes were confirmed by doing glycated hemoglobin test and their range is \>7.0%,
✓. age ranged from 30-65 years
✓. patients were willing to participate in this study

Exclusion criteria

✕. immunocompromised and patients with systemic diseases that can cause muscle weakness as Parkinson's disease, or others that can limit their cognitive functioning such as dementia
✕. pregnant
✕. nursing women
✕. smokers
✕. alcoholic patients were also excluded from the study.
✕. should not have a history of use of any drugs that can cause hyposalivation or broad spectrum antibiotics, within the last month.

What they're measuring

clinical assessment of erythematous/psuedomembranous oral candidiasis resolution

Timeframe: 28 days

Trial details

NCT IDNCT06072716

SponsorYasmine gamil

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-27

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